This review of the Antibiotic guidelines has been staggered. The September release is the second in the series and includes a revision of the Prevention of infective endocarditis topic. For information on other updates, see the
March and December What’s new pages.
For an overview of the guideline review process, including previous releases and topic groupings; see What’s new: Antibiotic.
Clindamycin is no longer recommended for endocarditis prophylaxis for dental procedures because of an increased risk of severe adverse reactions. For patients with a history of severe penicillin hypersensitivity, doxycycline or azithromycin is now recommended.
Institutions with high rates of endocarditis following transcatheter aortic valve implantation (TAVI) or cardiac implantable electronic device (CIED) procedures that use an inguinal approach are advised to consider incorporating antibiotics with enterococcal activity into their endocarditis prophylaxis strategy.
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